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Be sure to speak with your healthcare provider if you’re taking these supplements. In addition, the supplement contained other nutrients known for promoting hair growth like amino acids, zinc, and vitamin C, so it’s unclear if biotin affected the results (13). In fact, though advertisements may claim that these supplements promote hair growth, limited large-scale studies support this (7, 8). The FNB was unable to establish ULs for biotin because there is no evidence in humans that biotin is toxic at high intakes [1].
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Biotin Side Effects
Biotin deficiency is rare among healthy individuals since the nutrient is widely found in foods and is produced by your body. Pregnant women, children, people who misuse alcohol, and those with a biotinidase deficiency may be at higher risk. A lack of proper nutrients, including vitamins A, C, D, and E, zinc, B vitamins, iron, biotin, protein, and essential fatty acids, may slow hair growth or cause hair loss. There is no evidence that most people need to take biotin supplements, and there have been no reports of a severe biotin deficiency in any healthy person consuming a balanced diet. We found 18 reported cases of biotin use for hair and nail changes.
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They also provide a variety of B vitamins, zinc, and essential fatty acids. Deficiency in any of these nutrients may contribute to hair loss (1). However, high doses of biotin can interfere with lab tests by falsely skewing thyroid hormone levels, vitamin D levels, or other results, which could have a significant impact on your medical care (1, 13). Herein, with the help of experts, you’ll get the lowdown on biotin for hair growth and what you need to know before investing your time and money in biotin-based supplements to treat thinning.
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Limit milk/dairy (1-2 servings/day) and juice (1 small glass/day). No evidence in humans has shown a toxicity of biotin even with high intakes. Because it is water-soluble, any excess amount will leave through the urine. Each berry-flavored serving provides 33,333% of the DV for biotin. It’s also sugar-free, naturally flavored, vegetarian-friendly, non-GMO, and gluten-free. This organic, gluten-free, non-GMO, and vegan-friendly supplement is designed to promote collagen synthesis and improve the appearance of your skin.
Biotin and Healthful Diets
Several creams, supplements, and other remedies are sold online and in stores to help promote hair growth. However, many of these products lack scientific evidence, and more research is needed. Further research is needed to support the use of biotin supplements for this purpose in healthy individuals. A study published in 2015 found that women with thinning hair experienced some reduction in shedding after taking an oral marine protein supplement for 90 days. However, biotin was only one ingredient in this supplement, and the research was sponsored by a company that sells health and beauty products. Biotin is unlikely to cause adverse side effects, even in high doses.
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Biotin is a required cofactor for carboxylase enzymes that become activated once they are joined together by holocarboxylase synthase [18]. These enzyme complexes play an important role in multiple metabolic processes including gluconeogenesis, fatty acid synthesis, and amino acid catabolism [19]. Biotin's function in protein synthesis and more specifically, in keratin production, explains its contribution to healthy nail and hair growth. Biotin is readily found in many foods and is also produced by normal gut flora.
The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. “PowerCycle promotes the hair follicle’s antigen phase, which means they are waking up,” said Dr. Polen Koçak, the brand’s cofounder.
Biotin supplements can be found in various oral (by mouth) forms, including liquid, tablet, gummy, and capsule forms. The body can absorb 100% of biotin taken by mouth, even at high doses, unless absorption issues are present, like inflammatory bowel disease (IBD). Biotin's greatest claim to fame is its purported ability to strengthen hair and nails. Most support for these claims is anecdotal, but there is some promising scientific evidence, too.
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If you think you're not getting enough biotin in your diet, talk to your doctor about taking a daily supplement. As with hair, there's not enough scientific proof that biotin will give you longer, stronger nails unless you have a health condition that affects them. If you’re still willing to give biotin a try (you do you, buuut ideally not without talking to your doctor or derm first) despite the chance that it might not work, you’ve got a few options. Biotin can be used topically with a hair-growth shampoo or a thickening shampoo or, as we’ve mentioned, taken as an oral supplement, like in one of these top-rated options below. In the world of beauty supplements, biotin is treated as the magic fix—like the beauty equivalent of restarting your phone. You hear about it so often that you probably don’t even think to question it.
As that applies to PowerCycle, “We’ve taken the biotech, which is basically rocket science, and then we have biotin, which is a hot ingredient. Everyone’s searching for it on Google, but we’ve structured and engineered it unlike anyone else,” he said. Also, consider avoiding formulations that contain additives that might irritating to the scalp and inadvertently cause dryness or itchiness, such as harsh chemicals, dyes, and fragrances. Instead, seek out those that have been dermatologist-tested, says Dr. Shaver.
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It’s also widely available in supplement form, either by itself or combined with other vitamins and minerals (3, 4). However, little is known about biotin’s role in hair health and whether this supplement can truly help. Meanwhile, “the goal of a serum is to target the hair follicle directly by delivering compounds that may allow for improved or optimal hair growth,” says Dr. Mirmirani. These ingredients are those that aren’t typically found in the diet, such as minoxidil and plant-based compounds. Dietary avidin, a glycoprotein in raw egg whites, binds tightly to dietary biotin and prevents biotin’s absorption in the gastrointestinal tract [13,14].
Finally, 3 cases of brittle nail syndrome treated with biotin were found in the literature and each case showed improvement of nail strength as well as growth on either 2,500 or 3,000 μg of biotin/day. The evidence on biotin supplementation to treat brittle nails includes three small studies that did not include a placebo group, and these reports do not indicate the baseline biotin status of study participants. One of these studies assessed the effects of 2.5 mg/day biotin for 6–15 months in 22 women with brittle, splitting, or soft nails and 10 healthy volunteers [25]. In the eight patients with brittle nails whose nail samples were obtained immediately before and after biotin supplementation, nail thickness increased by 25%.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. For instance, seizure medications like carbamazepine (Tegretol), phenytoin (Dilantin), primidone (Mysoline), and phenobarbital (Luminal) may lower levels of this vitamin in your body (1). Excess intake of this vitamin has also been linked to the measurement of false troponin levels — used to indicate heart attacks — leading to delayed treatment and even death (14, 15, 16). Biotin supplements are known for interacting with certain diagnostic tests that use biotin-streptavidin technology, and this can lead to incorrect results (14, 15, 16). The most important step is to test your serum before using it for the first time.
However, it’s possible that there simply hasn’t been enough research on the potential side effects of taking too much (1). Note that high doses of biotin don’t appear to pose a risk of toxicity, although they may interfere with lab testing. Per serving, this supplement from Life Extension provides 2,000% of the DV for biotin. This is a relatively low dose compared with most other biotin-only supplements. Researchers have looked at the role of biotin in various skin conditions. They've linked a shortage of the vitamin to dermatitis, acne scarring, and other skin problems, but they need to do more research into how biotin levels affect your skin.
Even in cases where a biotin deficiency is present, biotin supplements may not necessarily prevent hair loss. In which case, you may be wondering if increasing your intake of biotin will lead to better hair growth. And any googling you may have done on the topic has likely brought up such claims. But first, it’s first important to know that there’s a difference between something that helps promote hair growth and something that helps prevent hair loss. If you miss taking biotin supplements for one or more days there is no cause for concern, since it takes some time for your body to become seriously low in biotin.
This fact sheet by the National Institutes of Health (NIH) Office of Dietary Supplements (ODS) provides information that should not take the place of medical advice. We encourage you to talk to your health care providers (doctor, registered dietitian, pharmacist, etc.) about your interest in, questions about, or use of dietary supplements and what may be best for your overall health. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. Biotinidase deficiency is a rare autosomal recessive disorder that prevents the body from releasing free biotin, leading to biotin deficiency despite normal intake. Without treatment, biotinidase deficiency produces neurological and cutaneous symptoms, and profound biotinidase deficiency can lead to coma or death [19,20].
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